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Tumor necrosis factor inhibition and glucose homeostasis
We report the development of hyperglycemia related to adalimumab therapy in a patient with psoriasis. (Source: Journal of the American Academy of Dermatology)MedWorm Sponsor Message: Have a look at The Arthritis Daily, the new arthritis portal powered by MedWorm, with all the latest news and research on arthritis updated daily.
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Bullae and psoriasiform hyperkeratosis after treatment with golimumab
To the Editor: Golimumab is a human monoclonal antibody that binds with high specificity and affinity to tumor necrosis factor (TNF)-alfa and is Food and Drug Administration approved for the treatment of moderate to severe rheumatoid arthritis, active psoriatic arthritis, and ankylosing spondylitis. This agent has also shown promise in the treatment of severe psoriasis. In the GO-REVEAL study, greater than 60% of patients with significant skin disease experienced a 75% reduction in the Psoriasis Area and Severity Index score when treated for 52 weeks. The safety of golimumab has been evaluated in at least 13 clinical trials, and although these studies did not demonstrate a large number of dermatologic complications, reports of such adverse effects have been observed. One striking outcome i...
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The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis.
Authors: Weix J, Häupl T, Raio L, Villiger PM, Förger F
Abstract
During pregnancy, most patients with rheumatoid arthritis (RA) experience a spontaneous improvement in their condition. Since type I interferons (IFN) have immunomodulatory properties, we investigated whether type I IFN-inducible genes are upregulated in pregnant patients with RA. Peripheral blood mononuclear cells were evaluated using quantitative real-time polymerase chain reaction for type I IFN-inducible genes (IFI 35, IFI44, IFI44L, IFIT3, OAS1, and Siglec1) in patients with RA and healthy women during and after pregnancy as well as in nonpregnant controls. IFN-alpha and IFN-beta levels in sera of patients and healthy donors were analyzed by enzyme linked immunosorbent assay. It was found that healthy women did...
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Immunomodulaton and attenuation of lethal influenza A virus infection by oral administration with KIOM-C.
In this study, we investigated the antiviral effect of KIOM-C for the treatment of influenza A virus infection. Our results show that oral administration of KIOM-C conferred a survival benefit to mice infected with the 2009 pandemic H1N1 [A(H1N1)pdm09] virus, and resulted in a 10- to 100-fold attenuation of viral replication in ferrets in a dose-dependent manner. Additionally, oral administration of KIOM-C increased the production of antiviral cytokines, including IFN-γ and TNF-α, and decreased levels of pro-inflammatory cytokines (IL-6) and chemokines (KC, MCP-1) in the Bronchoalveolar lavage fluid (BALF) of A(H1N1)pdm-infected mice. These results indicate that KIOM-C can promote clearance of influenza virus in the respiratory tracts of mice and ferrets by modulating cytokine production...
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Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative.
Authors: Hemshekhar M, Sunitha K, Thushara RM, Sebastin Santhosh M, Shanmuga Sundaram M, Kemparaju K, Girish KS
Abstract
Coumarins are a group of natural compounds widely distributed in plants. Of late, coumarins and their derivatives have grabbed much attention from the pharmacological and pharmaceutical arena due to their broad range of therapeutical qualities. A coumarin derivative 4-methylesculetin (4-ME) has known to possess effective antioxidant and radical-scavenging properties. Recently they have also shown to down regulate nuclear factor-kappa B (NF-κB) and protein kinase B (Akt) that play a vital role in inflammation and apoptosis. In view of this, the present study investigated the anti-arthritic potentiality of 4-ME by assessing its ability to inhibit cartilage and bon...
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MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis.
Authors: Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
Abstract
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies proinflammatory mediators and facilitates a wide range of inflammatory and autoimmune diseases. Interleukin (IL)-17-producing T-helper (Th)17 cells have a crucial role in RA pathogenesis, and IL-6 is the key factor promoting Th17 differentiation. We investigated whether the level of MRP8/MRP14 is positively associated with IL-6 and IL-17 levels in RA SF and found that MRP8/MRP14 level had a significant correlation with IL-6 and IL-17 levels in RA SF. We also observed that MRP8-induced IL-17 produc...MedWorm Sponsor Message: Have a look at The Arthritis Daily, the new arthritis portal powered by MedWorm, with all the latest news and research on arthritis updated daily.
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Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta.
Authors: Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM
Abstract
Infection with helminth parasites triggers strong and stereotypic immune responses in humans and mice, which can protect against specific experimentally-induced autoimmune diseases. We have shown that infection with the rat tapeworm, Hymenolepis diminuta, confers a protective effect on FCA-induced joint inflammation. Here, we investigated the effect of a prophylactic infection with H. diminuta on the K/BxN-serum model of polyarthritis in BALB/c mice. Mice were infected with 10 cysticercoids of H. diminuta by oral gavage and 8days later arthritis was induced by i.p. injection of K/BxN arthritogenic serum. Joint swelling and pain measurements were recorded throughout a 13day time ...
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Assessment of the frequency of different Borrelia burgdorferi sensu lato species in patients with Lyme borreliosis from north-east Poland by studying preferential serologic response and DNA isolates.
CONCLUSIONS: Both methods gave consistent results, indicating B.afzelii as the main agent of all the clinical forms of the Lyme borreliosis in the study area.
PMID: 23540208 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
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Video: Say What!? The Invisible Hearing Aid
TUCSON, Ariz. (Ivanhoe Newswire) -- Hearing loss is the third most common physical condition after heart disease and arthritis. Hearing aids used to be the only option for those with moderate to severe hearing loss, but now an invisible device is giving patients a new choice. (Source: Medical Headlines From Ivanhoe.com)
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Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis
(Johns Hopkins Medicine) In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe cases of the disease, the immune system makes a unique subset of antibodies that have a disease-promoting role. (Source: EurekAlert! - Social and Behavioral Science)
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Sugar Injections for Knee Arthritis May Ease Pain: Study
But at least one expert questions benefits of the alternative treatment (Source: WebMD Health)MedWorm Sponsor Message: Have a look at The Arthritis Daily, the new arthritis portal powered by MedWorm, with all the latest news and research on arthritis updated daily.
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Researchers Able To Prevent And Cure Type 1 Diabetes In Animal Models
Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed. The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis... (Source: Health News from Medical News Today)
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Common Foot Deformities Like Bunions Are Inherited
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot Study - the first to estimate the heritability of foot disorders in humans - appear in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology (ACR). Previous studies show that as many as 60% of older adults have foot disorders which may limit mobility and reduce their quality of life... (Source: Health News from Medical News Today)
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Joint Replacement Surgery Could Become A Thing Of The Past With New Theory On Genesis Of Osteoarthritis
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, they now have evidence that the bone underneath the cartilage is also a key player and exacerbates the damage. In a proof-of-concept experiment, they found that blocking the action of a critical bone regulation protein in mice halts progression of the disease... (Source: Health News from Medical News Today)
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Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption
Conclusions:
This study demonstrated that WESS inhibits osteoclast differentiation and function. These results suggest that WESS has a potential for treating pathological bone diseases caused by excessive bone resorption. (Source: BMC Complementary and Alternative Medicine)
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The roles of aryl hydrocarbon receptor in immune responses
A number of recent studies have examined the functions of aryl hydrocarbon receptor (Ahr) in the immune system. Also known as dioxin receptor, Ahr is a ligand-activated transcription factor that serves as a receptor for various environmental toxins. The functions of Ahr in T cells depend on the specific ligand bound to the receptor. For instance, binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to Ahr suppresses experimental autoimmune encephalomyelitis (EAE) by promoting the development of Foxp3+ Treg cells, whereas 6-formylindolo[3,2-b]carbazole enhances EAE by inducing the differentiation of IL-17-producing T cells. Furthermore, specifically deleting Ahr in T cells inhibits collagen-induced arthritis in mice. In macrophages and dendritic cells (DCs), Ahr is anti-inflammatory. In response ...MedWorm Sponsor Message: Have a look at The Arthritis Daily, the new arthritis portal powered by MedWorm, with all the latest news and research on arthritis updated daily.
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Study shows COPD is associated with significant and persistent pain
(American Thoracic Society) Chronic obstructive pulmonary disease is primarily associated with the respiratory symptoms that are its hallmark, but in fact, patients who struggle with the disease also experience significant amounts of chronic pain. A new study conducted by researchers in Pennsylvania and New Mexico estimates the degree of pain suffered by these patients to be close to that experienced by patients with osteoarthritis and rheumatoid arthritis. (Source: EurekAlert! - Medicine and Health)
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No-treatment approach may be best choice for older prostate cancer patients
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multi-center study led by researchers from the UCLA Department of Urology.
The study reports 14-year survival outcomes for 3,000 men diagnosed with prostate cancer between 1994 and 1995. The results suggest that older patients with low- or intermediate-risk prostate cancer who have at least three underlying health problems, or comorbidities, are much more likely to die of something other than their cancer.
"For men with low-to-intermediate–risk disease, prostate cancer is an indolent disease that doesn't pose a major risk to survival," said the study's first author, Dr. Timothy Daskivich, a UCLA Robe...
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Type 1 Diabetes May Be Reversible With Immune Suppressor Protein
A professor in Melbourne, Australia, who is on a mission to find a cure for type 1 diabetes, believes that the answer, or part of it, lies with an immune suppressor protein called CD52. And if it works for type 1 diabetes, then it may well work for other immune disorders, such as multiple sclerosis and rheumatoid arthritis, where disruption in the balance different kinds of T cell in the immune system causes it to attack the body's own healthy tissue... (Source: Health News from Medical News Today)
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Blame your parents for bunion woes
(Wiley) A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot Study -- the first to estimate the heritability of foot disorders in humans -- appear in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology. (Source: EurekAlert! - Social and Behavioral Science)
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